Unstable genomes promote inflammation

Markers of inflammation in unstable angina.

How two sites of inflammation promote carcinogenesis

We recently reported that anti-inflammatory macrophages contribute to the initiation of colorectal carcinogenesis in IBD patients by inducing epithelial-mesenchymal-transition associated alterations in colonic epithelial cells. In this process, TGFβ1 dependent upregulation of the adhesion molecule L1CAM is one key event, paving the way to colitis associated tumorigenesis and metastatic spread.

852-2 Widespread Coronary Inflammation In Patients With Unstable Angina

Background: Inflammation may cause unstable angina (UA) by favoring coronary plaque rupture and erosion, In UA activated leukocytes were found in peripheral and coronary sinus blood, but it is unclear whether they are selectively activated in the vascular bed of the culprit stenosis, Methods: We measured the difference in neutrophil myeloperoxidase content (MPXI) across the cardiac and femoral ...

Cardiac Angiotensin II Participates in Coronary Microvessel Inflammation of Unstable

Angiotensin (Ang) II is now recognized to be a mediator of a wide variety of inflammatory processes. This study investigated renin-angiotensin system (RAS) components and a number of inflammatory mediators in left ventricular biopsies from 2-vessel disease unstable angina (UA) (n 43) and stable angina (SA) (n 15) patients undergoing coronary bypass surgery. Biopsy samples from 6 patients underg...

Microparticles from mycobacteria-infected macrophages promote inflammation and cellular migration.

Mycobacterium tuberculosis infection is characterized by a strong inflammatory response whereby a few infected macrophages within the granuloma induce sustained cellular accumulation. The mechanisms coordinating this response are poorly characterized. We hypothesized that microparticles (MPs), which are submicron, plasma membrane-derived vesicles released by cells under both physiological and p...